SARS-CoV-2 Vaccines: Much Accomplished, Much to Learn

Whole-inactivated SARS-CoV-2 vaccines: from fear to hope

Undoubtedly, vaccination can be one of the promising approaches to control infectious diseases such as the COVID-19 pandemic. Inactivated viral vaccines have a history of "vaccine-induced enhanced disease", which may occur when neutralizing antibodies bind to viral antigens without blocking or clearing the infection. This can cause additional inflammation through the mechanisms described for ot...

Splicing: still so much to learn.

This issue marks the 20th year since the launching of RNA in March of 1995. It is a time to celebrate, as well as to consider the substantial accomplishments achieved in these two decades, both in the RNA field as a whole, and in the specific areas in which each of us works—in my case, human premRNA splicing mechanisms and regulation, and its relevance to human disease. Moreover, this is a time...

Exercise induced asthma, still much to learn.

Lipoprotein (a)—We Know So Much Yet Still Have Much to Learn …

L ipoprotein(a) (Lp[a]) has been identified as an independent , causal risk factor for cardiovascular disease (CVD). 1,2 Lp(a) has a structure similar to low-density lipopro-tein (LDL) in its lipid core composition in addition to a molecule of apolipoprotein B 100 (apoB), but also contains a unique glycoprotein—apo(a), with strong structural homology with plasminogen. 2 Apo(a) contains anything...

SARS-CoV-2 infection: its psychiatric manifestations

Background:  The clinical presentation of SARS-CoV-2 infection was initially dominated by respiratory symptoms. However the clinical spectrum is wide and neuropsychiatric syndromes are also a source of medical concern. Our aims are to present an atypical clinical presentation of SARS-CoV-2 infection characterized by auditory hallucinations and unusual behavior and to emphasize the diversity of ...